36. Krieg C, Weber LM, Fosso B, Marzano M, Hardiman G, Olcina MM, Domingo E, El Aidy S, Mallah K, Robinson MD, Guglietta S. Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy. J Immunother Cancer. 2022 Sep;10(9):e004717. doi: 10.1136/jitc-2022-004717. PMID: 36137652; PMCID: PMC9511657.
35. Guglietta S, Krieg C. Phenotypic and functional heterogeneity of monocytes in health and cancer in the era of high dimensional technologies. Blood Rev. 2022 Sep 1:101012. doi: 10.1016/j.blre.2022.101012. Epub ahead of print. PMID: 36114066.
- Marzena Swiderska-Syn, Júlia Mir-Pedrol , Alexander Oles, Olga Schleuger, April D Salvador, Sean M Greiner, Cara Seward, Fan Yang, Benjamin R Babcock , Chen Shen, Daniel T Wynn, Avencia Sanchez-Mejias, Timothy R Gershon, Vanesa Martin, Heather J McCrea, Kathryn G Lindsey, Carsten Krieg, and Jezabel Rodriguez-Blanco. Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse. Sci Adv. 2022 Jul 22;8(29)
33. Rubinstein MP, Williams C, Mart C, Beall J, MacPherson L, Azar J, Swiderska-Syn M, Manca P, Gibney BC, Robinson MD, Krieg C, Hill EG, Taha SA, Rock AD, Lee JH, Soon-Shiong P, Wrangle J. Phase I Trial Characterizing the Pharmacokinetic Profile of N-803, a Chimeric IL-15 Superagonist, in Healthy Volunteers. J Immunol. 2022 Mar 15;208(6):1362-1370. doi: 10.4049/jimmunol.2100066.
32. Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O’Quinn EC, Horton JD, Dubinett SM, Paulos CM, Neskey DM, Lo RS. Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma. Cell Rep Med. 2021 Oct 19;2(10):100411. doi: 10.1016/j.xcrm.2021.100411.
31. Zielinski JM, Luke JJ, Guglietta S, Krieg C. High Throughput Multi-Omics Approaches for Clinical Trial Evaluation and Drug Discovery. Front Immunol. 2021 Mar 31;12:590742. doi: 10.3389/fimmu.2021.590742. eCollection 2021.
30. Knochelmann HM, Dwyer CJ, Smith AS, Bowers JS, Wyatt MM, Nelson MH, Rangel Rivera GO, Horton JD, Krieg C, Armeson K, Lesinski GB, Rubinstein MP, Li Z, Paulos CM. IL6 Fuels Durable Memory for Th17 Cell-Mediated Responses to Tumors. Cancer Res. 2020 Sep 15;80(18):3920-3932. doi: 10.1158/0008-5472.CAN-19-3685.
29. Shaul ME, Eyal O, Guglietta S, Aloni P, Zlotnik A, Forkosh E, Levy L, Weber LM, Levin Y, Pomerantz A, Nechushtan H, Eruslanov E, Singhal S, Robinson MD, Krieg C, Fridlender ZG. Circulating neutrophil subsets in advanced lung cancer patients exhibit unique immune signature and relate to prognosis. FASEB J. 2020 Mar;34(3):4204-4218. doi: 10.1096/fj.201902467R.
28. Metelli A, Wu BX, Riesenberg B, Guglietta S, Huck JD, Mills C, Li A, Rachidi S, Krieg C, Rubinstein MP, Gewirth DT, Sun S, Lilly MB, Wahlquist AH, Carbone DP, Yang Y, Liu B, Li Z. Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β. Sci Transl Med. 2020 Jan 8;12(525). pii: eaay4860. doi: 10.1126/scitranslmed.aay4860.
27. Galli E, Hartmann FJ, Schreiner B, Ingelfinger F, Arvaniti E, Diebold M, Mrdjen D, van der Meer F, Krieg C, Nimer FA, Sanderson N, Stadelmann C, Khademi M, Piehl F, Claassen M, Derfuss T, Olsson T, Becher B. GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis. Nat Med. 2019 Aug;25(8):1290-1300. doi: 10.1038/s41591-019-0521-4.
26. Mariani SA, Li Z, Rice S, Krieg C, Fragkogianni S, Robinson M, Vink CS, Pollard JW, Dzierzak E. Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells. Immunity. 2019 Jun 18;50(6):1439-1452.e5. doi: 10.1016/j.immuni.2019.05.003. Epub 2019 Jun 6. PubMed PMID: 31178352; PubMed Central PMCID: PMC6591003.
25. Cassetta L, Baekkevold ES, Brandau S, Bujko A, Cassatella MA, Dorhoi A, Krieg C, Lin A, Loré K, Marini O, Pollard JW, Roussel M, Scapini P, Umansky V, Adema GJ. Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates. Cancer Immunol Immunother. 2019 Apr;68(4):687-697. doi: 10.1007/s00262-019-02302-2.
24. Chatterjee S, Chakraborty P, Daenthanasanmak A, Iamsawat S, Andrejeva G, Luevano LA, Wolf M, Baliga U, Krieg C, Beeson CC, Mehrotra M, Hill EG, Rathmell JC, Yu XZ, Kraft AS, Mehrotra S. Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response. Clin Cancer Res. 2019 Feb 1;25(3):1036-1049. doi: 10.1158/1078-0432.CCR-18-0706.
23. Wrangle J, Velcheti V, Patel MR, Garrett-Mayer E, Hill EG, Ravenel J, Miller J, Anderton J, Taffaro-Neskey M, Sherman C, Suriano S, Swiderska-syn M, Harris J, Sion A, Edwards A, Rytlewski JA, Sanders CM, Yusko EC, Robinson MD, Krieg C, Farhad M, Redmond WL, Lindsey K, Egan JO, Rhode PR, Jeng EK, Rock A, Wong HC, Rubinstein MP.
Safety and Activity of the IL-15/IL-15R Complex ALT-803 in Combination with the anti-PD-1 mAb Nivolumab in Metastatic Non-Small Cell Lung Cancer. Lancet Oncology 2018 April. FOF
22. Krieg C*, Nowicka M, Guglietta S, Schindler S, Hartmann FJ, Dummer R, Robinson M, Levesque M*, Becher B*.
High dimensional analysis of the immune landscape during anti-PD-1 immunotherapy of melanoma predicts responsiveness.
Nature Medicine. Advance Online Publication (AOP). Jan 2018, doi : 10.1038/nm.4466 (*Corresponding authors).
21. Wang Y, de Valliere C, Imeney Silva PH, Leonardi I, Gruber S, Gerstengrasser A, Melham H, Weber A, Leucht K, Wolfram L, Hausamann M, Krieg C, Thomasson K, Boyman O, Frey-Wagner I, Rogler G, Wagner CA.
The proton-activated receptor GPR4 modulates intestinal inflammation.
J Crohns Colitis. 2017 Nov 9. [Epub ahead of print]
20. Nowicka M, Krieg C, Weber LM, Hartmann FJ, Guglietta S, Becher B, Levesque MP, Robinson MD.
CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets.
F1000Research 2017 May 26;6:748.
19. Hartmann FJ, Bernard-Valnet R, Queriault C, Mrdjen D, Weber LM, Galli E, Krieg C, Robinson MD, Nguyen X-H, Dauvilliers Y, Liblau R, Becher B.
Immune Signature of Narcolepsy Revealed by High-Dimensional Single-Cell Analysis.
J. Ex. Med. 2016 Nov 14213(12):2621-2633.
18. Woytschak J, Keller N, Krieg C, Guglietta S, Impellizzieri D, Thompson RW, Wynn TA, Zinkernagel AS, Boyman O.
Type II IL-4 receptor expression on neutrophils antagonizes their expansion and migration during infection and inflammation.
Immunity. 2016 Jul;45(1):172-84.
17. Guglietta S, Chiavelli A, Zagato E, Krieg C, Gandini S, Ravenda PS, Bazolli B, Lu B, Penna G, Rescigno M.
Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis.
Nat. Commun. 2016 Mar;7:11037.
16. Mair F, Hartmann FJ, Mrdjen D, Tosevski V, Krieg C, Becher B.
The end of gating? An introduction to automated analysis of high dimensional cytometry data.
Eur J Immunol. 2016 Jan; 46(1):34-43.
15. Chijioke O, Müller A, Feederle R, Barros MH, Krieg C, Emmel V, Marcenaro E, Leung CS, Antsiferova O, Landtwing V, Bossart W, Moretta A, Hassan R, Boyman O, Niedobitek G, Delecluse HJ, Capaul R, Münz C.
Human natural killer cells prevent infectious mononucleosis features by targeting lytic epstein-barr virus infection.
Cell Rep. 2013 Dec;5(6):1489-98.
14. Bouchaud G, Gehrke S*, Krieg C*, Kolios A, Hafner J, Navarini AA, French LE, Boyman O.
Epidermal IL-15Ra acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.
J Exp Med. 2013 Sep;210(10):2105-17.
*equally contributing second authors.
13. Iolyeva M, Aebischer D, Proulx ST, Willrodt AH, Ecoiffier T, Häner S, Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O, Chen L, Finke D, Halin C.
Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage.
Blood. 2013 Sep;122(13):2271-81.
12. Jungraithmayr W, Codarri L, Bouchaud G, Krieg C, Boyman O, Gülvüszi G, Becher B, Weder W, Münz C.
Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells.
Am J Respir Crit Care Med. 2013 Jun;187(12):1349-59.
11. Boyman O, Krieg C, Homann D, Sprent J.
Homeostatic maintenance of T cells and natural killer cells.
Cell. Mol. Life Sci. 2012 May; 69(10): 1597-608.
10. Levin AM*, Bates DL*, Ring AM*, Krieg C*, Lin JT, Su L, Raeber ME, Bowman GR, Novick P, Pande VS, Kohrt HE, Fathman CG, Boyman, O, Garcia, KC.
Exploiting a Natural Conformational Switch to Engineer an Interleukin-2 Superkine.
Nature. 2012 Mar; 484(7395): 529-33.
*equally contributing first authors.
9. Krieg C, Létourneau S, Pantaleo G, Boyman O.
Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells.
Proc Natl Acad Sci U S A. 2010 June; 107(26): 11906-11.
8. Létourneau S, van Leeuwen EM, Krieg C, Martin C, Pantaleo G, Sprent J, Surh CD, Boyman O.
IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor a subunit CD25.
Proc Natl Acad Sci U S A. 2010 Feb; 107(5): 2171-6.
7. Boyman O, Létourneau S, Krieg C, Sprent J.
Homeostatic proliferation and survival of naïve and memory T cells.
Eur J Immunol. 2009 Aug; 39 (8): 2088-94.
6. Létourneau S, Krieg C, Pantaleo G, Boyman O.
IL-2- and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets.
J Allergy Clin Immunol. 2009 Apr; 123(4): 758-62.
5. Krieg C, Boyman O.
The role of chemokines in cancer immune surveillance by the adaptive immune system.
Semin Cancer Biol. 2009 Apr; 19(2): 76-83.
4. Krieg C, Boyman O, Fu YX, Kaye J.
B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation.
Nat Immunol. 2007 Feb; 8(2): 162-71.
3. Krieg C, Han P, Stone R, Goularte OD, Kaye J.
Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells.
J Immunol. 2005 Nov; 175(10): 6420-7.
2. Krieg C, Maier R, Meyerhans A.
Gut-homing (a(4)b(7)(+)) Th1 memory responses after inactivated poliovirus immunization in poliovirus orally pre-immunized donors.
J Gen Virol. 2004 Jun; 85: 1571-9.
1. Heintel T, Sester M, Rodríguez MM, Krieg C, Sester U, Wagner R, Pees HW, Gärtner B, Maier R, Meyerhans A.
The fraction of perforin-expressing HIV-specific CD8 T cells is a marker for disease progression in HIV infection.
AIDS. 2002 Jul; 16(11): 1497-501.
https://www.ncbi.nlm.nih.gov/pubmed/12131187